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2017
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2017
OMIG Abstract 2
Seasonal Trends in Adenovirus Conjunctivitis: A 30-Year Study
J Lee, R Bilonick, EG Romanowski, RP Kowalski
The Charles T Campbell Laboratory, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Purpose: The objective of this observational study is to assess if there is a seasonal trend to human adenoviral (HAdV) conjunctivitis in a multi-center academic healthcare network during a 30-year period. We postulate that there is no seasonal trend. To our knowledge, this will be the longest time period of data collected for HAdV conjunctivitis.
Methods: A total of 926 positive cases of HAdV conjunctivitis were reviewed at the University of Pittsburgh Medical Center (UPMC) in Pittsburgh (Allegheny County, Pennsylvania, United States) from March 11, 1987 to December 15, 2016. Conjunctival samples were collected in viral transport media (Bartels ClamTransTM) and tested positive for HAdV in cell-culture. To determine seasonal variation, the daily counts were adjusted for yearly changes in Allegheny County population size; modeled as a function of long-term trend using Basis-spline (B-spline); analyzed for seasonal trend by quarter (Q1=January to March, Q2=April to June, Q3=July to September, Q4=October to December). The second quarter (Q2) was used as a reference point.
Results: The number of adenovirus conjunctivitis cases in Q3 was 45% higher than in Q2 (95% confidence interval [CI] 1.21-1.74, P = 0.0001). This is compared to Q1 and Q4, which were not statistically significant (95% CI 0.96-1.42, P = 0.1209 and 95% CI 0.96-1.41, P = 0.1180, respectively). From 1987 to 1996 and from 1997 to 2007, the lowest number of cases reported occurred in Q2. Then from 2008 to 2016, the lowest number of cases reported occurred in Q4.
Conclusion: We observed a higher number of cases from July to September in our study population. Knowledge of seasonality can be used to guide outbreak expectations and disease prevention.
Disclosure: None
2017
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